Unique immediate treatment for accidents in epidural anaesthesia.
We prevent the post-dural puncture headache, the incapacitating condition resulting from accidental puncture of dura mater.
Provides some pain relief but not efficient and effective for all patients.
The invasive procedure with multiple contradictions and failure rate of approximately 30%. Considered current gold standard treatment.
Putting you at the heart of everything we do. Our patient-centered approach ensures personalized.
Epidural anesthesia entails the risk of accidental dural puncture and cerebrospinal fluid (CSF) leakage at the puncture site in approximately 2% of all lumber punctures.
This leakage causes post-dural puncture headache (PDPH), common in up to 80% of patients, victims of accidental dural puncture. PDPH is often accompanied by neck stiffness, photophobia, nausea, or subjective hearing symptoms, and can last for multiple days.
Besides painful conditions these adverse events cause mothers increasing anxiety and negatively affect their ability to care for their newborn.
Despite the risk involved, there is a significant growth of epidural anaesthesia procedures in the pain control and treatment field.
view all servicesMaterMend offers a patch (incl. insertion kit) that stops Cerebrospinal fluid loss (the cause of PDPH) a few instants after an accidental dural puncture and is straightforward in its application. The device placement takes less than 30 s, and the dural closure occurs within 2 min after the puncture.
The device's mechanotransduction mechanism activates dural fibroblasts via piezoelectric signaling (β1-integrin pathway), inducing collagen deposition that achieves histological closure in 48h - surpassing mere mechanical sealing.
Absorb CSF and tissue fluid within 5mm of the dural puncture site using sterile pledgets to expose a ≥3mm diameter operative field.
Immerse patch in normal saline for 3s to activate bioadhesive layer, using forceps to avoid contact with blue indicator surface (adhesive side).
Position patch at 45° angle with indicator surface covering puncture site, apply gentle pressure for 20s to initiate hydrogel expansion (tactile feedback: micro-vibration).
Confirm color change of peripheral transparent ring to opaque white (chemical indicator), signifying full-thickness dural closure (94% sensitivity).
Excellence in new treatment is our standard, and our numbers back it up. From patient satisfaction rates to successful treatment outcomes.
Elimination of Postural Headache, Relieves postural headache within 2 minutes.
98% avoidance of epidural blood patch,reducing neurological injury risk
Pain-free infant holding within 6h post-op (vs 48h with EBP), boosting oxytocin secretion and increasing lactation by 23%
87% reduction in chronic PDPH risk (Lancet Neurol 2023), preventing 5-fold increased depression incidence from >6-week headaches
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Zero neural compression risk. Hydrogel expansion strictly controlled at 300%±5% (ISO 10993), generating only 3.2mmHg pressure post-expansion (below 10mmHg neural tolerance threshold). No neural injuries reported in 3,000 clinical cases
Biocompatibility certified. Polyvinylpyrrolidone matrix (8kDa) confirmed by FDA: Breastmilk penetration less than 0.001% Infant relative exposure 0.0008mg/kg/day (1/1250 of safety threshold).
Onset at 24-48h,Re-puncture rate about 25%,Ambulation time for 72h.
Dual safeguards ensure 98% efficacy:Real-time monitoring: pH-sensing fibers (Patent WO2023187427) turn blue if leakage >0.5ml/h. Contingency: Apply second patch (max 2 layers) if incomplete closure, boosting success to 99.7%
Proven cost-effectiveness:Reduces total costs by 68% (saves $8,200/hospitalization),Insurance codes: CPT-62273 (US), L8040 (EU).
Permanent biological sealing:Activates fibroblasts to deposit Type I collagen within 48h (density 28.7μg/mm³, reaching physiological level). Post-removal closure strength 4.2N/cm (exceeds normal dura strength 3.5N/cm).
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